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From S14E01"Pilling Them Softly'' Family Guy
Lois is informed by Stewie's teacher Miss Tammy that he has an attention problem.
She takes him to Dr.
Hartman, who promptly gives him a prescription to treat ADHD.
When he takes the pills, he becomes totally placid.
Brian is initially upset about this, but when Meg mentions the creative benefits of it, he decides to try it himself.
They both begin to act out of the ordinary.